Papers from Feb 8 2010 Journal Club

Here are the papers we talked about in yesterday's Journal Club:

PLoS Biol. 2010 Jan 26;8(1):e1000294.
Rare variants create synthetic genome-wide associations. See my previous coverage of this paper and the comments.
Dickson SP, Wang K, Krantz I, Hakonarson H, Goldstein DB.

PLoS Genet. 2010 Jan;6(1):e1000798. Epub 2010 Jan 8.
Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.
Igl W, Johansson A, Wilson JF, Wild SH, Polasek O, Hayward C, Vitart V, Hastie N, Rudan P, Gnewuch C, Schmitz G, Meitinger T, Pramstaller PP, Hicks AA, Oostra BA, van Duijn CM, Rudan I, Wright A, Campbell H, Gyllensten U; EUROSPAN Consortium.

Science. 2010 Jan 7. [Epub ahead of print]
A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection.
Grossman SR, Shylakhter I, Karlsson EK, Byrne EH, Morales S, Frieden G, Hostetter E, Angelino E, Garber M, Zuk O, Lander ES, Schaffner SF, Sabeti PC.